Genetics of gestational trophoblastic disease

The abnormal pregnancies complete and partial hydatidiform mole are genetically unusual, being associated with two copies of the paternal genome. Typical moles (CHMs) diploid androgenetic, while (PHMs) diandric triploids. While diagnosis can usually be made on basis morphology, ancillary techniques that exploit their unusual genetic origin used to facilitate diagnosis. Genotyping p57 immunostaining now routinely in differential moles, for investigating mosaic or chimeric products conception a molar component identifying rare diploid, biparental HMs an inherited predisposition pregnancies. also plays important role gestational non-gestational trophoblastic tumours identification causative pregnancy where gestational. Recent developments include use cell-free DNA non-invasive these conditions.